Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Verena Moosmann avatar Verena Moosmannorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoLucille Delisle avatar Lucille Delisleorcid logoKatarzyna Kamieniecka avatar Katarzyna KamienieckaDevon Ryan avatar Devon RyanGildas Le Corguillé avatar Gildas Le CorguilléWilliam Durand avatar William Durandorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoKrzysztof Poterlowicz avatar Krzysztof PoterlowiczEkaterina Polkh avatar Ekaterina Polkhorcid logoSaskia Hiltemann avatar Saskia Hiltemannorcid logoPavankumar Videm avatar Pavankumar VidemJoachim Wolff avatar Joachim Wolfforcid logoWolfgang Maier avatar Wolfgang Maierorcid logoMartin Čech avatar Martin Čechorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoMallory Freeberg avatar Mallory Freebergorcid logoMaria Doyle avatar Maria Doyleorcid logoArmin Dadras avatar Armin DadrasFriederike Dündar avatar Friederike DündarVivek Bhardwaj avatar Vivek Bhardwajorcid logoCristóbal Gallardo avatar Cristóbal GallardoMehmet Tekman avatar Mehmet TekmanNiall Beard avatar Niall Beardorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoFlorian Heyl avatar Florian HeylLeily Rabbani avatar Leily RabbaniFidel Ramirez avatar Fidel Ramirezorcid logoBjörn Grüning avatar Björn GrüningTorsten Houwaart avatar Torsten Houwaartorcid logoBérénice Batut avatar Bérénice BatutMélanie Pétéra avatar Mélanie Pétéraorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoHelena Rasche avatar Helena Rascheorcid logoMo Heydarian avatar Mo Heydarianorcid logoAnup Kumar avatar Anup Kumar

Funding

These individuals or organisations provided funding support for the development of this resource

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ELIXIR Europe
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Australian BioCommons
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UFR
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de.NBI
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Melbourne Bioinformatics
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The University of Melbourne
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Collaborative Research Centre 992