Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

William Durand avatar William Durandorcid logoMaria Doyle avatar Maria Doyleorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoCristóbal Gallardo avatar Cristóbal GallardoMehmet Tekman avatar Mehmet Tekmanorcid logoMallory Freeberg avatar Mallory FreebergLeily Rabbani avatar Leily Rabbaniorcid logoLucille Delisle avatar Lucille DelisleFriederike Dündar avatar Friederike DündarJoachim Wolff avatar Joachim Wolfforcid logoBérénice Batut avatar Bérénice Batutorcid logoYvan Le Bras avatar Yvan Le BrasMélanie Petera avatar Mélanie Peteraorcid logoMartin Čech avatar Martin Čechorcid logoArmin Dadras avatar Armin DadrasVerena Moosmann avatar Verena Moosmannorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoFlorian Heyl avatar Florian HeylNiall Beard avatar Niall BeardGildas Le Corguillé avatar Gildas Le CorguilléTorsten Houwaart avatar Torsten HouwaartFidel Ramirez avatar Fidel RamirezEkaterina Polkh avatar Ekaterina Polkhorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoPavankumar Videm avatar Pavankumar VidemVivek Bhardwaj avatar Vivek Bhardwajorcid logoBjörn Grüning avatar Björn GrüningDevon Ryan avatar Devon Ryanorcid logoHelena Rasche avatar Helena Rascheorcid logoMo Heydarian avatar Mo Heydarianorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoAnup Kumar avatar Anup Kumarorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoSaskia Hiltemann avatar Saskia Hiltemann

Funding

These individuals or organisations provided funding support for the development of this resource

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Australian BioCommons
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de.NBI
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The University of Melbourne
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UFR
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Collaborative Research Centre 992
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ELIXIR Europe
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Melbourne Bioinformatics