Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Devon Ryan avatar Devon RyanNiall Beard avatar Niall BeardTorsten Houwaart avatar Torsten Houwaartorcid logoBjörn Grüning avatar Björn GrüningMélanie Pétéra avatar Mélanie Pétéraorcid logoPavankumar Videm avatar Pavankumar Videmorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoCristóbal Gallardo avatar Cristóbal GallardoWilliam Durand avatar William Durandorcid logoFlorian Heyl avatar Florian Heylorcid logoYvan Le Bras avatar Yvan Le BrasGildas Le Corguillé avatar Gildas Le Corguilléorcid logoWolfgang Maier avatar Wolfgang MaierEkaterina Polkh avatar Ekaterina Polkhorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoHelena Rasche avatar Helena Rascheorcid logoKhaled Jum'ah avatar Khaled Jum'ahFriederike Dündar avatar Friederike Dündarorcid logoAmirhossein Naghsh Nilchi avatar Amirhossein Naghsh Nilchiorcid logoNicola Soranzo avatar Nicola SoranzoLeily Rabbani avatar Leily RabbaniMehmet Tekman avatar Mehmet Tekmanorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoAnup Kumar avatar Anup Kumarorcid logoMaria Doyle avatar Maria DoyleVerena Moosmann avatar Verena Moosmannorcid logoAnika Erxleben avatar Anika ErxlebenJoachim Wolff avatar Joachim Wolfforcid logoBérénice Batut avatar Bérénice Batutorcid logoMallory Freeberg avatar Mallory Freebergorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoMo Heydarian avatar Mo Heydarianorcid logoMartin Čech avatar Martin Čechorcid logoSaskia Hiltemann avatar Saskia HiltemannFidel Ramirez avatar Fidel Ramirezorcid logoArmin Dadras avatar Armin DadrasVivek Bhardwaj avatar Vivek Bhardwajorcid logoLucille Delisle avatar Lucille Delisle

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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The University of Melbourne
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Collaborative Research Centre 992
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de.NBI
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Australian BioCommons
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ELIXIR Europe
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Melbourne Bioinformatics